Higurashi: When They Cry (2006)

S1E4 The Hidden Demon Chapter - Part 4 - Distortion

Keiichi sinks into utter hopelessness. Having been seized and drugged into unconsciousness, he comes to find himself bound at the hands of Mion and Rena, who try to force a strange serum into him. In a frenzy, Keiichi kills them both, then ends his own life by tearing open his throat with his bare hands.